Seema Alexander

Seema Alexander is an AI Business Futurist, international keynote speaker, and serial entrepreneur on a mission to empower 1 million CEOs to rewire their businesses for the AI era—unlocking new levels of intelligence, operational leverage, and long-term competitive advantage.

As Founder & CEO of Disruptive AI, she leads a team helping the world's most ambitious leaders rewire their businesses for the AI era.

A former Fortune 500 executive — 13 years at Prudential Financial across five businesses — turned serial entrepreneur, Seema brings over two decades of experience in brand repositioning, growth strategy, and innovation. She has guided hundreds of organizations—from legacy enterprises to high-growth startups—through moments of disruption, helping them not just adapt, but fundamentally reimagine how they operate, compete, and create value.

Through her global keynotes, AI fluency experiences, and The AI CEO Podcast, Seema is shaping how non-technical CEOs and business leaders understand and operationalize AI. Her core belief: this is not a technology upgrade—it's a business rewiring. The companies that win will be those that build intelligence into the core of how decisions are made, how work is executed, and how value is created.

She is also a mother of two daughters—an identity that deeply shapes her perspective on this moment. For Seema, the rise of AI is not just a business inflection point, but a responsibility: to help build a future where technology expands human potential, preserves what makes us uniquely human, and creates meaningful opportunity for the next generation.

Seema is also the founding partner of AI BusinessCon—the world's first business rewiring conference for the AI era, taking place March 2–3, 2027 in the Washington, DC metro area (registration now open)—and former Co-Chair of DC Startup & Tech Week.